A Black Man’s Tribute to His White Mother Essay

James McBride, has an individual component in its cause that is conveyed all through the content. The creator endeavored to perceive his race, and revealed the contacting story of his Jewish mother who encountered her very own Diaspora: she moved from Poland to Virginia, and from Virginia to New York City. The last move took a lot of boldness, since she needed to desert both her confidence and her family so as to follow her heart, eventually wedding the nominal dark man and establishing an enduring family. The previously mentioned individual component truly helps convey the account forward: James McBride wishes to recount to his own story, yet understands that he can't tell his own without telling his mother’s. Purposefully or not, this works very well on a meta-literary level, as it strengthens how firmly fastened his family is to each other, which fills in as an extraordinary contradiction to her other family (without a doubt, her other life) that she abandoned in Virginia. See more: Homelessness as a social issue Essay The work additionally serves to facilitate a truly necessary (at that point, as much as now) conversation in regards to racial division inside America. A nonpartisan spectator may see the caption of the work and inquire as to why race is so essential to the story; as McBride outlines, one can't talk about this specific story of migration, life, and accomplishment with regards to America without examining the prejudice that saturated the country†¦how, even in the shadow of social liberties triumphs, many considered race to be a reason to separate, instead of a chance to meet up. In spite of the somewhat genuine reason, the book at last appears to be more elevating than discouraging. The journals of times when race relations are so awful likewise serve to make one appreciative that current day America is substantially more middle of the road with respect to issues of race (however not, obviously, great). McBride astutely inserts this thought in the very title of his work, suggesting that the shade of waterâ€transparent clarityâ€can just get through a blend of race rather than isolation. The idea of compromise inside the work isn't constrained to issues of race: the epilog of the story highlights McBride getting more in contact with his Jewish legacy, viably bringing the excursion of his mom round trip: as she needed to abandon Judaism so as to manufacture another life and another personality, James McBride needs to re-find it as a method of deciding his own character. All through the work, there is a propensity of the significance of instruction. The content underlines that each of the twelve of Ruth McBride’s youngsters become school instructed, and perusers feel each knock en route as she attempts to get them through school. In any case, even while finding out about these monetary challenges (a generally unstable subject in the shadow of close to financial breakdown), perusers are offered a brief look at trust: the work exchanges sections composed by James and parts composed by his mom, so even as the account makes one worried for how the kids will turn out, the grasping story of James reminds crowds that they will turn out fine and dandy. As it were, that is the example of this book: pressure and discharge, strain and release†¦the pressure of Ruth’s battle with her old family, and the arrival of the accomplishment with her new family. There is the strain of budgetary hardships and the arrival of money related achievement. Also, in a story that is basically about the American dream, pressure originates from the likelihood that America may not be prepared for Ruth’s dream. Thus, the discharge is the delight of Ruth not making due with the American dream: rather, she makes and realizes her own. The Gentle People: A Portrait of the Amish by James Warner gives a private investigate a gathering that is as yet a riddle to numerous Americans: the Amish. Consistent with its promise, the book is essentially contained photos of the Amish that are falsely made to appear as though cleaned out, â€Å"antique† photographs. These are generally joined by a scriptural section, so one can all the more appropriately get into the Amish outlook. The old versus joined with the bygone feel of the photos truly gives an inclination that one has become â€Å"unstuck in time,† as Vonnegut would state. Would-be sociologists will see this book as a fortune trove of data in regards to Amish society, especially with respect to connections. As per the book, open warmth between wedded people is profoundly disapproved of by Amish society, as their love for each other is too consecrated to possibly be imparted to pariahs. As ought not be astounding, a considerable lot of the thoughts are established in Christian compositions and have been embraced by Christian scholars, however the Amish take things to their sensible extraordinary: John Donne, for example, advised sweethearts not to sob at their beloved’s memorial service, on the grounds that the warmth was too important to even think about sharing with untouchables. The Amish have taken Donne’s exhortation about affection after death and have applied it to cherish during life, which can be something of a stun when one first finds out about it. Obviously, cutting edge women's activists will discover much inside the book that is upsetting to their motivation. The Amish have acknowledged Ephesians, and carefully anticipate that spouses should submit to their husbands in all issues. There are even cutoff points to how much youngsters can be presented to the educational system, with the suspicion that no one but God can give shrewdness, and everything else is absurdity. While these are essential statutes for Mormons and underestimated in their general public, it is shaking for spectators (especially liberal spectators) to initially observe the quantity of limitations that are put on individuals and articulations. Luckily, the creator has a worked in ethos: James Warner was destined to a Mennonite family unit, so he has a considerable amount of foundation in regards to this issue. In any case, that is the thing that makes the book baffling on a few levels: it doesn't worry about any profound disclosures about Amish history, and doesn't work well for as a prologue to the Amish way of life essentially in light of the fact that no verifiable setting is advertised. The book and its photographs are advanced as a sort of â€Å"slice of life† perspective on the Amish†¦however, taking into account that it was first printed more than four decades prior (and was apparently offering outdated substance even in those days), the work battles to locate an appropriate crowd in the present day. All things considered, it's anything but a book for the Amish: its photos and sections are basically repetitive for them, and increasingly preservationist Amish may even consider its writer something of a traitor†¦a man who surrendered their private way of life, just to make a benefit by publically attacking that security. The book is additionally not proposed for those needing to completely find out about the Amish: as explained on above, it doesn't dive into their history, and offers no setting for the activities taken by the Amish. The perfect crowd for this book, strangely enough, would be present day photography buffs: the photos are very striking, and the measures taken to cause them to appear to be more antiquated than they are might just offer the hopeful picture taker new deceives for their tool kit. For every other person? There are much better books about the Amish, particularly for the individuals who wish to know their full story.

“Medea” Aristotelian Analysis

Aristotelian Analysis †Music/Sound and Spectacle (Medea) V. Music/SoundThe Use of Sound in Medea Eurypides utilizes sound to incredible impact in Medea. Maybe most pervasive is the way that all the ladies are played by men, undoubtedly talking and singing in a shrill falsetto, giving the play a high, shrieking tone, which would absolutely bother the crowd. This would add to the pressure, and give a misrepresented complexity between the men, talking in their common voices, and the ladies in their falsetto.This additionally impacts the melodic idea of the play. When contrasted with other Greek catastrophes where the chorale would have been purposefully all male, Medea would have a totally different sound, a significantly more ladylike sound, as would be fitting for one of only a handful hardly any Greek plays with a female hero. The language Eurypides utilizes enables the crowd to get her and her activities, just as have the option to sympathize with her. Expressions of annihilati on, for example, â€Å"kill,† â€Å"broken,† â€Å"refugee,† â€Å"sick,† â€Å"hate,† â€Å"enraged,† and â€Å"starves† all set the phase in the initial 20 lines of the play.The crowd immediately realizes that Medea has endured terribly, and now has each privilege and motivation to deliver retribution for the wrongs that have been done to her. These equivalent words are utilized frequently all through the play, particularly â€Å"hate† and â€Å"betrayed† and give us incredible knowledge into the absolute rage and determination of Medeas later activities. Jason's words, then again, assist us with acknowledging exactly how disengaged he is. He is, as the Chorus says â€Å"ignorant past pity. †Ã¢ Jason thinks he is being â€Å"generous,† and he by one way or another thinks leaving his better half for a more youthful lady makes him her â€Å"advocate. Eurypides cautiously underscores the scene where the yo ungsters are butchered by having it be the main time we hear them talk. They are in front of an audience for some scenes, yet they sit idle however watch, quiet and faithful while their family self-destructs around them. At the point when they at last talk, it is on the grounds that it is their lone any expectation of sparing themselves; it is past the point of no return for their family. They shout out, with youthful blameless voices, arguing for help in what is maybe the most tense snapshot of the play.This strain is additionally uplifted by the way that the crowd can't perceive what's going on, they can just hear it. They are compelled to depend on sound alone, and that sound for those couple of lines turns into the main thing that issues. One nearly needs to watch Medea slaughter her kids just to recognize what is really occurring behind that entryway as opposed to being denied maybe our most significant sense: sight. The crowd gets heedless to the activity of the play, as Medea has grasped her visually impaired wrath. Social Implications:In the last lines of Medea, Euripides utilizes the verbal association among Jason and Medea to show an inversion in the cliché sexual orientation jobs of the time. Despite the fact that Medea is a goddess, she speaks to a solid, unflinching female job that has control over her male partner in their relationship. Minutes before the last terrific display, a distressed, debilitated Jason is weak to the desire of Medea. He raises his voice (demonstrative of his losing all power and lamentably lashing out for some structure control) and requests that he be permitted to have his kids back.Yet Madea is unflinching and industrious. In contrast to Jason, she â€Å"wastes† no words and gives a straightforward, discerning sounding message that mirrors her incomparability. This sort of social editorial is fascinating in light of the fact that ladies, who were seldom granted the freedoms of men at that point, were permitted to go to the plays at the Dionysus celebration. It is conceivable that Euripides was sending an inconspicuous message of expectation and pride to the entirety of the mistreated female individuals from his crowd. Dialect:Euripides was praised for his oversimplified utilization of language which mirrors a progressively practical discourse in the character's demeanors. Despite the fact that he didn't win the same number of the lead position grants as Sophocles or Aeschylus at the Dionysus celebrations, his work was mainstream to a crowd of people which had the option to perceive their own tongues and accents in front of an audience. In contrast to different catastrophes of his time, Euripides' work was not weakened by ridiculous, self important manner which frequently deleteriously affected the audience's appreciation and capacity to interprate the plays.Physical Realities of Sound in Ancient Greek Theater: Ancient Greek performance centers were uncommonly developed to superbly suit the craftsmanship which they housed (despite the fact that without rooftops). The multi-thousand-seat theaters were incorporated with hilsides to consider insignificant development and furthermore astounding accoustics. In the present theater, sound is quite often electronically enhanced to allow better hearing by the crowd, however not having this as an alternative, these grecian sanctuaries must be built perfectly.By enclosing the orchestraâ with a numerically culminated plan of wooden or stone seats, slanting upwards away from the exhibition, the old engineers almost mimiced the way that sound goes as it spreads. This close immaculate acoustical condition permitted the entertainers' voices to go right to the last column of seats. Additionally, the Skene buidling which remained behind the symphony may have aided the intensification by reflecting voices and sound towards the a great many crowd members.This course of action implied that the words which were verbally expressed and hint s of music and moving were clear with the end goal that their significance could be heard precisely. The venues of Ancient Greece colossal, when, for instance, the closest seat was very nearly 10 meters from the entertainer, enormous developments and uproarious voices were basic to passing on the full story. All things considered, it is broadly acknowledged that the entertainers would wear exceptionally basic, plain covers which made their facial highlights all the more clear and evident for the crowd to see.Some theater history specialists attest that these covers additionally had a kind of bull horn worked in for enhancement, in spite of the fact that this point is questioned. Related to their extended appearances, the entertainers were regularly on braces and wearing substantial robes of texture to precisely pass on their character. These changes to their body implied that each move they made and each solid they made should have been justified, despite all the trouble. There was no â€Å"stage whispering† in this theater which restricted yet additionally motivated Euripides to compose plays with progressively powerful and complex plotlines, ones loaded up with activity and showdown to futher add to the experience.In option, the chorale of somewhere in the range of twelve men (playing ladies in Medea) would continually move around the ensemble (got from the Greek expression for moving) during their scenes. The moving was engaging yet additionally permitted the gathering to spread around the riches so to talk about their tributes, with the goal that all may be conscious of hearing their sound and seeing their move. VI. Display The Greatest Spectacle: After the uncommon hardships which Medea faces all through the play, we run over the closure when she â€Å"appears in a winged chariot, transcending the house. The assemblages of the two youngsters are obvious in the chariot. Curiously, in the course of the last 1570 lines of the play, the stage bearings are rarely this particular or expand. Demonstrating that Euripides has actually held back something special for later, maybe to indecently introduce a major closure, the rising chariot is the encapsulation of scene in this play. In spite of the fact that there would be no such chariot in the old theaters, all things considered, Medea herself would be lifted from the stage level by the deus ex machina (truly, god machine) and the childen's bodies would be pushed forward on a moving wagon from the skene in the back of the orchestra.By making such a display, Euripides additionally features the significance of this occasion: Medea has murdered her own childen so as to liberate them from the dread of the world which has been made for them. Her activities show her madness, and her steady quest for retribution against Jason. Setting and Costumes: The one of a kind Greek theaters which situated a large number called for shortsighted yet clear structure decisions. Rather than expand outfits , the entertainers would wear enormous striking ensembles which permitted even the most distant observer to be sure about who is who.Due to the broadly recognized â€Å"three-on-screen character rule† (whereby three on-screen characters assumed the jobs of the considerable number of characters in a play) the ensemble and cover changes would need to quickly reflect varying characters. It is likewise generally acknowledged that the entertainers would wear a kind of braces to make them â€Å"larger than life† prompting two translations: the on-screen characters could be better observed and heard when higher, yet additionally turned out to be practically divine or ridiculously enormous adding to the exhibition of this world. Doorways and Exits:In the back of the symphony segment was the Skene, an enormous structure which filled in as an all inclusive setting for Greek Theater. The occasionally intricate structure would by and large have a significant entryway in the middle (for royal residence settings) just as machines which lifted entertainers over the ensemble segment. A few characters may have entered along these lines, yet most, including the ensemble, would enter entrance ramps nearby the symphony region. These eisodoi or parodoi would be utilized for passages by characters, for example, a delivery person or fighter. How did the entertainers move:Simply, the on-screen characters moved in enormous, exaggerated movements. So as to make the play as clear as workable for the enormous crowds, nuance was impossible for the antiquated Greeks. In any case, what this additionally meantâ for the presentation was that the plot must be suitably gotten ready for this style of acting. Entertainers did in some cases long talks with exceptionally clear enthusiastic aim. This style is a urgent piece of Medea. As the plot proceeds and Medea's circumstance intensifies, feelings become progressively polar and incoherent, clarifying the p

10 Drugs That Can Cause Depression

10 Drugs That Can Cause Depression Many people are not aware that there are certain prescription drugs that can cause depression symptoms as a side effect, even in people who might not ordinarily be prone to depression.  In addition, people with a history of depression may want to either avoid these medications or use them with caution, since they can exacerbate their existing illness. A 2018 study published in JAMA found that more than a third of U.S. adults are currently taking a prescription medication that could potentially cause depression or increase suicide risk.?? Types of Drugs That Can Cause Depression While not a comprehensive list, the following are 10 common types of drugs that may cause depression symptoms. You should consult with a doctor or pharmacist for information about your own specific medication regimen. Beta-Blockers Beta-blockers are generally prescribed in the treatment of high blood pressure, although they may also be used to treat  migraines, angina, irregular heartbeat, and tremors.  They may also be given as eye drops in the treatment of glaucoma. There is some debate about the degree to which these medications may cause depression, but they are commonly associated with depression symptoms such as sexual problems and fatigue.?? Examples of this type of drug include  Toprol XL (metoprolol) and Inderal (propranolol). Corticosteroids These medications are used to treat inflammatory conditions, such as lupus, rheumatoid arthritis, gout, and Sjögrens syndrome. Corticosteroids can cause a variety of psychiatric symptoms. It is thought that among other effects, corticosteroids affect serotonin, a substance produced by the brain which is believed to be involved in mood regulation.?? Examples of this type of medication include cortisone, prednisone, methylprednisolone, and triamcinolone. The Relationship Between Steroids and Bipolar Disorder Benzodiazepines These drugs are usually used in the treatment of anxiety and insomnia or when it is necessary to cause the muscles to relax. In certain circumstances, the drug can build up in the body, leading to depression symptoms.?? Common examples of benzodiazepines include Xanax (alprazolam), Restoril (temazepam), and Valium (diazepam). Parkinsons Drugs These are drugs used in the treatment of Parkinsons disease. These drugs affect a substance in the brain called dopamine, which is also one of the basic chemicals which are associated with depression.  Scientists believe that when these drugs cause dopamine to become elevated for long periods of time, it may also affect a persons mood.?? The most commonly used medication in treating Parkinsons disease is levodopa.  Other common medications that may be used include Atamet and Sinemet (carbidopa/levodopa); and Sinemet (carbidopa); Mirapex (pramipexole); and Requip (ropinirole). Drugs That Affect Hormones These drugs include hormonal forms of birth control as well as estrogen replacement therapy for menopausal symptoms. Variations in hormone levels in women are often associated with depression symptoms, although it is not completely understood how this interaction occurs. Research suggests that progestin-only birth control is unlikely to cause symptoms of depression.?? How Estrogens Can Cause Anxiety and Depression Stimulants Stimulant medications may be prescribed to treat daytime sleepiness associated with conditions like narcolepsy, and they may also be used in the treatment of attention deficit hyperactivity disorder (ADHD). These medications are known to influence the amount of dopamine in the brain in a way that may contribute to depression in certain individuals.?? Ritalin (methylphenidate) and Provigil (modafinil) are some examples of this type of medication. Anticonvulsants These drugs used in the treatment of seizures, although they may also be used in treating other conditions, such as bipolar disorder and neuropathic pain. Because they affect the chemicals in the brain that are also believed to be responsible for regulating mood, they can sometimes cause depression.?? Some examples of this type of medication include Tegretol (carbamazepine), Topamax (topiramate), and Neurontin (gabapentin). Proton Pump Inhibitors (PPIs) and H2 Blockers These medications are most commonly prescribed to treat gastroesophageal reflux disease (GERD) and have occasionally been associated with depression for reasons that arent clear.?? Statins and Other Cholesterol-Lowering Drugs While statins are the most commonly prescribed drugs for lowering cholesterol, other drugs, such as fibrates, colesevelam, ezetimibe, and nicotinic acid can also be used for this purpose. There have been some reports linking these drugs with depression. It is thought that these drugs may cause depression by lowering the levels of cholesterol in the brain, where it serves many important functions.?? Anticholinergic Drugs Anticholinergic drugs influence a variety of functions in the body, including slowing down the action of the intestines. They are often used in the treatment of irritable bowel syndrome (IBS) with medications like Bentyl (dicyclomine). The way that they work is by blocking acetylcholine, a substance that causes musclesâ€"such as those in the intestinal tractâ€"to contract and create movement.  However, because they affect the central nervous system, they can also cause depressive symptoms. Other Drugs That Can Cause Depression Some other medications that may be linked to depressive side effects include:Acne medicationsPain relieversAntiseizure medicationsAnxiety medicationsAllergy medicationsAcid reflux medicationsAntidepressantsThyroid medicationsAntibiotics How to Know If a Medication Is Making? You Depressed The most noticeable symptom of depression is, of course, a feeling of sadness and low mood.  Other than a depressed mood, however, there are other possible symptoms of depression that you might experience, like the following: Feelings of hopelessness or helplessnessFeelings of guilt or worthlessnessAnxietyIrritability and restlessnessFatigue and low energyProblems with sleepProblems with appetite or weightProblems with thinking, memory, and concentrationLoss of interest in things once enjoyedThoughts of death or suicide It can be helpful to write down details like when your symptoms first started and when they are the most severe. With many medications, you may begin to start noticing such symptoms within the first few weeks after you begin a new drug. Because many medications that can cause depression are not prescribed to treat mental health conditions, people may not be adequately warned of this possible risk. It is also difficult to know what your individual reaction to a drug may be, or how it may interact with other medications that you are currently taking. For this reason, it is important to always fully inform your doctor about anything else you are taking, including any over-the-counter medications and herbal supplements. Always talk to your doctor if you experience any unusual side effects after taking a medication. What to Do Next If you believe that you may be experiencing symptoms of depression, whether they are related to a drug that you are taking or not, you should consult with your personal physician. Do not stop taking your medication without your doctors permission.  If you are experiencing severe depression or having thoughts of suicide, do not hesitate to seek immediate medical attention. Every situation is different, so your doctor will look at your health history and symptoms in order to determine what steps to take next. In some cases, it may involve switching to a different medication or adjusting your dosage. Your doctor will also try to determine if your depressive symptoms are linked to the new medication or some other cause. If there is an underlying depressive disorder that is unrelated to prescription medication, your doctor may recommend other treatments such as antidepressants and psychotherapy. The Best Online Resources for Depression

Symptoms And Treatment Of Alzheimer s Disease - 1780 Words

When you think of Alzheimer s disease, the first thing that comes to mind is memory loss. This is something that may affect a family member, a close friend, a coworker, or someone dear to our heart. Currently, there is no cure for it, yet due to extensive research, there are more treatment options for it. The available medications that have been approved by the FDA can possibly slow the progression of the disease, but it is a temporary benefit. Research is ongoing and recent developments in treatment has occurred in the last fifteen years. The name was derived from a German physician Dr. Alois Alzheimer. He is the one that first discovered the brain disorder in a female patient and continued studying her brain even after her†¦show more content†¦Being suspicious of everyone and making false accusations of close friends and family members may seem normal, but when it accompanies memory loss, it should be checked out by a physician. The symptoms may start as early as the thirties, but they do not become more prominent until the senior years. Symptoms of dementia can be triggered by high blood pressure, diabetes, or coronary artery disease. Additional testing has not confirmed this. Crystal (2015) It is always best to see a physician before a self-diagnosis and take a series of tests to get a positive diagnosis just to be sure. It is now one of the leading causes of death. One out of three senior citizens will die from it or another form of dementia. The average life expectancy is eight to ten years. There are myths behind what causes Alzheimer’s. A half a century ago, it was believed that if you consumed any beverage from an aluminum can that you were susceptible to getting it. Equal was feared to cause many health problems and this was just another one to add to the list but no studies have linked the two to date. The flu shot is widely believed to cause more harm than good, but this myth has also been ruled out. The mercury content in dental fillings was believed to be a contributing factor and science disproved this theory. We hope one day there will be a cure or treatments which progressively slows down

A Conflict Of Your Choice Since The End Of The Cold War Essay

Analyse a conflict of your choice since the end of the Cold War, identifying the main parties (direct and indirect actors) and issues, explaining the conflict and relating it to its social or international context and how these factors have evolved over the life-cycle of the conflict. This should be done with a conceptual underpinning of the type of conflict being examined and within the organisational framework of conflict mapping. The conflict I will analyse is the Iraq War, met the standard definition of a war, more than 1000 people dying a year, every year from 2003-2016. I will argue that the main issues are: Oil; the Gulf War; the Regional situation; Ethnic/religious division in the long-term, and terrorism in the short term. Countries dependent on primary commodities exports are more likely to experience violent conflict (Social Development Department, World Bank, 2005). Oil security, and specifically oil security in the Gulf, had been part of US military strategy for thirty years prior to the invasion in 2003 (Ritchie Rogers, 2007). In 1981, Iraq was identified as a threat: as even before the Iraqi–Iranian war such a contingency exerted a major influence on U.S. force planning for non-NATO contingencies; Iraq’s Soviet-supplied armed forces are the largest of any in the Gulf region; and the principal oil fields of Kuwait and Saudi Arabia are within comparatively easy reach from Iraq’s southern border (Ritchie Rogers, 2007). By 2000, Iran was still hostile to theShow MoreRelatedCanada And The Cold War1514 Words   |  7 Pages Canada and the Cold War The Cold War is a time of managed political and military coercion and turmoil between the superpowers. It was a war that actually wasn t your common war. 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A car was approaching in the dark when several American soldiers were patrolling a main road of northern Iraq’s Tal Afar which was a  town rife with insurgents. ConcerningRead MoreThe Improbable War By Christopher Coker2146 Words   |  9 PagesIn Christopher Coker’s book The Improbable War, is explaining to the reader why a war between The United State and China, is not impossible but, improbable meaning that it is possible. The author states that we can learn from history if we take the right lessons from it. The book is showing what the proper lessons from the world’s history are. The book aims to have the reader by the end not rule out the chance of war between the two major powers. One the rising power quickly becoming the second biggest

Changing Behavior Case Analysis Free Essays

Changing Behavior Case Analysis Carlissa Tigue Psychology Narketta Sparkman Baker College October 25, 2012 The client, Mrs Freeman has been a drinker for 15 years and she currently drinks a fifth of Vodka a day and a six pack of beer. She is the mother of three girls and three boys. She has developed health issues related to her long term drinking habit. We will write a custom essay sample on Changing Behavior Case Analysis or any similar topic only for you Order Now Mrs. Freeman wants to quit drinking for her own health and the health of her children. Classical conditioning could explain Mrs. Freeman’s drinking addition. Her drinking acted as an unconditioned stimulus. As she continued to drink, she craved for more drinks and then stronger drinks this becomes her unconditioned response. Over time social, environmental and psychological influences became the conditioned stimulus for Mrs. Freeman’s drinking habit. When Mrs. Freeman finds herself in certain situations that make her feel uncomfortable her conditioned response is to have a drink. An example of this would be that Mrs. Freeman finds having depending solely on herself stressful, so she has a drink or two or maybe three. Mrs Freeman knows that this is not the behavior she wants to continue but because of classical conditioning (Morris Maisto, p. 153), she continues to drink whenever possible. The negative effects of her drinking are poor health for her and her children. The cost of buying liquid and beer on a regular bases are things Mrs. Freeman wants to stop. Mrs Freeman could use classical conditioning to learn to quit drinking. She also could go to AA meetings and get a sponsor. The meetings would be the unconditioned stimulus (Morris Maisto, p. 154). Every time Mrs. Freeman wants a drink she could go to a meeting or call her sponsor. Mrs. Freeman should pay attention to things that upset her and led her to having a drink. She should continue to go to her AA meetings and talking to her sponsor. In time the continued behavior of going to AA and speaking with her sponsor would become her conditioned stimulus. When Mrs Freeman finds herself in a situation that she cannot handle, she calls her sponsor or attend a meeting, this would become her conditioned response to situation that she cannot handle. Operant Conditioning could also play a part in Mrs. Freeman’s drinking habit. Mrs. Freeman started drinking when she was younger, as she got older she drunk more due to pressure. She continued to drink because she had so much going on, that she could not handle. The good feeling associated with drinking acted as a positive reinforcement, that made her continue her behavior. Now that Mrs. Freeman is grown and all on her own drinking has had a negative effect on Mrs. Freeman’s life. She has gone to work drinking, and been warn not to do it again. This has not stop Mrs. Freeman from drinking, she now just hides her drinking better. Mrs. Freeman knows that if she continues this behavior, she could loss her job. She has been affected by both positive and negative reinforcement (Morris Maisto, p 159). The negative reinforcement of drinking is poor health and the possibility of losing her job. These things have made Mrs. Freeman motivated to quit drinking. Instead of having a drink Mrs. Freeman will call her sponsor or even have a cup of coffee. She will reward herself by buying herself a new dress every time, she doesn’t pick up a drink. Mrs. Freeman is motivated to quit drinking for her health and the health of her children. Cognitive and social learning also play a role in maintain unwanted behaviors (Morris Maisto, p 174). Growing up with a father who was drinking everyday played a part in Mrs. Freeman’s emotional state. She grew up not knowing that the same thing could happen to her. Mrs Freeman saw her father drinking every day, she stole drinks when her father was not around. Mrs. Freeman modified her behavior so that her mother nor father knew she was drinking. Seeing her father get yelled at by her mother led Mrs. Freeman to learning how to not get caught drinking. When she reached adulthood, she had tried to quit drinking on several occasion. She felt that it was something wrong with her. As a young adult just finishing school Mrs. Freeman felt overwhelmed, and the drinking become worst. This type of behavior is known as learned helplessness (Morris Mastio, p. 164). My conclusion is that after speaking with Mrs Freeman, and hearing her story with drinking. Mrs. Freeman will continue to seek help to overcome her addition. With the right people and motivation, she will be fine. Mrs. Freeman will live a productive life in society if she continues to follow the plans that she has set forth. How to cite Changing Behavior Case Analysis, Essay examples

Changing Behavior Case Analysis Free Essays

Changing Behavior Case Analysis Carlissa Tigue Psychology Narketta Sparkman Baker College October 25, 2012 The client, Mrs Freeman has been a drinker for 15 years and she currently drinks a fifth of Vodka a day and a six pack of beer. She is the mother of three girls and three boys. She has developed health issues related to her long term drinking habit. We will write a custom essay sample on Changing Behavior Case Analysis or any similar topic only for you Order Now Mrs. Freeman wants to quit drinking for her own health and the health of her children. Classical conditioning could explain Mrs. Freeman’s drinking addition. Her drinking acted as an unconditioned stimulus. As she continued to drink, she craved for more drinks and then stronger drinks this becomes her unconditioned response. Over time social, environmental and psychological influences became the conditioned stimulus for Mrs. Freeman’s drinking habit. When Mrs. Freeman finds herself in certain situations that make her feel uncomfortable her conditioned response is to have a drink. An example of this would be that Mrs. Freeman finds having depending solely on herself stressful, so she has a drink or two or maybe three. Mrs Freeman knows that this is not the behavior she wants to continue but because of classical conditioning (Morris Maisto, p. 153), she continues to drink whenever possible. The negative effects of her drinking are poor health for her and her children. The cost of buying liquid and beer on a regular bases are things Mrs. Freeman wants to stop. Mrs Freeman could use classical conditioning to learn to quit drinking. She also could go to AA meetings and get a sponsor. The meetings would be the unconditioned stimulus (Morris Maisto, p. 154). Every time Mrs. Freeman wants a drink she could go to a meeting or call her sponsor. Mrs. Freeman should pay attention to things that upset her and led her to having a drink. She should continue to go to her AA meetings and talking to her sponsor. In time the continued behavior of going to AA and speaking with her sponsor would become her conditioned stimulus. When Mrs Freeman finds herself in a situation that she cannot handle, she calls her sponsor or attend a meeting, this would become her conditioned response to situation that she cannot handle. Operant Conditioning could also play a part in Mrs. Freeman’s drinking habit. Mrs. Freeman started drinking when she was younger, as she got older she drunk more due to pressure. She continued to drink because she had so much going on, that she could not handle. The good feeling associated with drinking acted as a positive reinforcement, that made her continue her behavior. Now that Mrs. Freeman is grown and all on her own drinking has had a negative effect on Mrs. Freeman’s life. She has gone to work drinking, and been warn not to do it again. This has not stop Mrs. Freeman from drinking, she now just hides her drinking better. Mrs. Freeman knows that if she continues this behavior, she could loss her job. She has been affected by both positive and negative reinforcement (Morris Maisto, p 159). The negative reinforcement of drinking is poor health and the possibility of losing her job. These things have made Mrs. Freeman motivated to quit drinking. Instead of having a drink Mrs. Freeman will call her sponsor or even have a cup of coffee. She will reward herself by buying herself a new dress every time, she doesn’t pick up a drink. Mrs. Freeman is motivated to quit drinking for her health and the health of her children. Cognitive and social learning also play a role in maintain unwanted behaviors (Morris Maisto, p 174). Growing up with a father who was drinking everyday played a part in Mrs. Freeman’s emotional state. She grew up not knowing that the same thing could happen to her. Mrs Freeman saw her father drinking every day, she stole drinks when her father was not around. Mrs. Freeman modified her behavior so that her mother nor father knew she was drinking. Seeing her father get yelled at by her mother led Mrs. Freeman to learning how to not get caught drinking. When she reached adulthood, she had tried to quit drinking on several occasion. She felt that it was something wrong with her. As a young adult just finishing school Mrs. Freeman felt overwhelmed, and the drinking become worst. This type of behavior is known as learned helplessness (Morris Mastio, p. 164). My conclusion is that after speaking with Mrs Freeman, and hearing her story with drinking. Mrs. Freeman will continue to seek help to overcome her addition. With the right people and motivation, she will be fine. Mrs. Freeman will live a productive life in society if she continues to follow the plans that she has set forth. How to cite Changing Behavior Case Analysis, Essay examples

Ocean Pollution Essay Example

Ocean Pollution Paper You authorized the report on September 23. At your request the formal report presents information on ocean pollution and how it affects the earth. This report presents information in three broad categories: top zone, second zone, third zone. The report includes the six cos of communication and PAP format. As always, helping you with this report and future endeavors is anticipated. So Ocean Pollution Prepared for Prepared by Antonio Burped September 26, 2013 Table of Contents Transmittal Memorandum Title Page 1 Table of contents 2 TOP zone 3 Second Zone 4 Third Zone 5 Conclusion 6 Currently, ocean pollution is a significant issue affecting the oceans and the rest of the earth. Problems like oil spills, toxic wastes, garbage, vehicle pollutants, global warming hazards, and other detrimental materials are all kinds of pollution that damages oceans every day. Ocean pollution directly affects aquatic life and indirectly affects humans and resources. Water shelters 70 percent of the planet making up rivers, lakes, and oceans. Scientists trust the worlds largest garbage dump is found in that water. (The Great Pacific Garbage patch, 2011) There are three zones that make up the ocean: the top zone, second zone, and third zone, all of which are polluted from different things and different reasons. Top Zone The topmost region of the ocean is termed the Epiphytic Zone or sunlight zone. Here you will trace most oceanic life where algae can cultivate lucratively and the temperature is kindlier, which is inviting to most sea creatures. (Surface Area and the Seabed Area, 2010) This zone is roughly 600 et deep, but is the nominal precinct out of the three. We will write a custom essay sample on Ocean Pollution specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Ocean Pollution specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Ocean Pollution specifically for you FOR ONLY $16.38 $13.9/page Hire Writer One of the numerous kinds of contamination in this zone is oil pollution. This is triggered by ships either leaking, or carrying oil that crash in the sea. Whenever you take your boat out for a good time, it is actually polluting the marine. The boats running engine can kill animals with the chemicals in the exhaust, and the extra gas the engine gives off. Another type of effluence that is most times associated with ocean pollution is garbage dumping, which includes trash, human waste, bathing water, and plastics. Garbage dumping is found in roughly the top 90 feet of the ocean. In that 90 feet you can find six times more pieces of plastic than there is plankton, which is the main food source for many of the sea creatures in the top zone. (Ocean Pollution) (Out of sight, Out of Mine, 2009) Second Zone The second zone is known as the Despotic Zone or twilight zone. Practically no sunlight will ever see this zone, resulting in very few plants being able to grow. The only animals you will find here are those that live with very little sunlight, exceedingly cold water, and extremely high pressure. This zone is ,400 feet making it the second largest zone. Pollution in this zone includes metals and toxic chemicals. These chemicals come from Agriculture causes. Chemical pesticides or fertilizers used to kill harmful insects or substances on land, are the chemicals that are poisoning the fish population. When rain hits plants on land, the pesticides and fertilizers get taken out and run off into the oceans. (Ocean Pollution, 201 1) The chemicals then settle at the bottom of the ocean and eventually are eaten by fish. Ocean Pollution Essay Example Ocean Pollution Paper You authorized the report on September 23. At your request the formal report presents information on ocean pollution and how it affects the earth. This report presents information in three broad categories: top zone, second zone, third zone. The report includes the six cos of communication and PAP format. As always, helping you with this report and future endeavors is anticipated. So Ocean Pollution Prepared for Prepared by Antonio Burped September 26, 2013 Table of Contents Transmittal Memorandum Title Page 1 Table of contents 2 TOP zone 3 Second Zone 4 Third Zone 5 Conclusion 6 Currently, ocean pollution is a significant issue affecting the oceans and the rest of the earth. Problems like oil spills, toxic wastes, garbage, vehicle pollutants, global warming hazards, and other detrimental materials are all kinds of pollution that damages oceans every day. Ocean pollution directly affects aquatic life and indirectly affects humans and resources. Water shelters 70 percent of the planet making up rivers, lakes, and oceans. Scientists trust the worlds largest garbage dump is found in that water. (The Great Pacific Garbage patch, 2011) There are three zones that make up the ocean: the top zone, second zone, and third zone, all of which are polluted from different things and different reasons. Top Zone The topmost region of the ocean is termed the Epiphytic Zone or sunlight zone. Here you will trace most oceanic life where algae can cultivate lucratively and the temperature is kindlier, which is inviting to most sea creatures. (Surface Area and the Seabed Area, 2010) This zone is roughly 600 et deep, but is the nominal precinct out of the three. We will write a custom essay sample on Ocean Pollution specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Ocean Pollution specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Ocean Pollution specifically for you FOR ONLY $16.38 $13.9/page Hire Writer One of the numerous kinds of contamination in this zone is oil pollution. This is triggered by ships either leaking, or carrying oil that crash in the sea. Whenever you take your boat out for a good time, it is actually polluting the marine. The boats running engine can kill animals with the chemicals in the exhaust, and the extra gas the engine gives off. Another type of effluence that is most times associated with ocean pollution is garbage dumping, which includes trash, human waste, bathing water, and plastics. Garbage dumping is found in roughly the top 90 feet of the ocean. In that 90 feet you can find six times more pieces of plastic than there is plankton, which is the main food source for many of the sea creatures in the top zone. (Ocean Pollution) (Out of sight, Out of Mine, 2009) Second Zone The second zone is known as the Despotic Zone or twilight zone. Practically no sunlight will ever see this zone, resulting in very few plants being able to grow. The only animals you will find here are those that live with very little sunlight, exceedingly cold water, and extremely high pressure. This zone is ,400 feet making it the second largest zone. Pollution in this zone includes metals and toxic chemicals. These chemicals come from Agriculture causes. Chemical pesticides or fertilizers used to kill harmful insects or substances on land, are the chemicals that are poisoning the fish population. When rain hits plants on land, the pesticides and fertilizers get taken out and run off into the oceans. (Ocean Pollution, 201 1) The chemicals then settle at the bottom of the ocean and eventually are eaten by fish.

Discover 8 ways to side-hustle online

Discover 8 ways to side-hustle online Eight ways to side-hustle online There’s nothing more desired for a student than an effortless side-hustle that won’t keep him or her running low on the budget. One thing you will need is basically an internet connection. Start earning! Matching Bets One of the easiest ways to get fast cash with minimum investment. Technically, you don’t use your own money, and you don’t lose anything. You don’t need to have smarts to understand the ground rules, neither do you need to know the betting terminology. To put it simply, multiple betting websites in the US offer free vouchers for your sign up, and they also send you offers like free $5 bet. This is where your money lies, once you get your hands on the free bet deals, you will make a bet against yourself, but on a different gambling outlets. In this way, your betting both for and against an outcome on two separate platforms, and since for each win you get an additional money bonus, you cannot be ripped off. Some matching tools can help you see where the bets are pretty much similar or nearly identical, so it helps you evaluate the best match and bet on it. With matching bets, you can earn as much as $1500! Online Surveys It’s an attractive ground for people who wish to earn extra pocket money in a snap. Research companies are always in need of honest opinion from people about a new product launch or on a topic of social matters. You can earn up to $5 for completing a single survey. The more online surveys you’ll find the more money you can get by answering multiple questions on different websites. As a rule, you have to reach a certain amount of money before you can withdraw them, so be aware that each site applies its own rules. Web Surfing The most effortless way to earn money yet! You just have to do what you already do, literally use the internet. Simply register on one of the websites that offer money for clicking the links and start earning by randomly clicking on every ad that you see on the websites. The more click - the more you earn. Then you can easily transfer your money to the PayPal account and withdraw them.    Market Trading This might be complicated at some point, but once you get ahold of the basics, it can bring you a big buck in a minute. For the beginners, several online stock markets offer free practice accounts, so that you can get to learn some general ideas and make your first trade with guides. Unlike any other way of making money online, the stock markets are extremely risky regarding losing your money if you make a mistake. So, in this case, it’s better to manipulate little amounts of money and be very careful with your decisions. Best to research the whole industry and get to learn from others before trading a lot of money! Set up your own Website Create your small business online with little effort and reap the benefits a real boss. Building your website is not as difficult as it might seem at first sight, but you still need a good foundation before you start for sure. And also, you’ll need to have some startup money, but it’s a worthwhile investment. Start your website in three simple steps: Buy a domain name Order web hosting service Create your design When everything is set up, use the power of social networks to advertise your business. And when you get ahold of the techniques and strategies, you’ll get top traffic sales. Review websites apps for cash Yet another simple way to earn money without digesting too many guides. Turn into a website tester and get $10 per site. You really need nothing more than an updated laptop, decent internet connection and a basic English knowledge. As a tester, you need to determine whether a website is user-friendly regarding design, navigation, quality, and ease-of-use for an average visitor. By the end of your review, you should make a small report in a written form describing all the pros and cons of the website. â€Å"Get Paid to† websites These sites offer you such activity as clicking the ads, taking mini tasks and passing surveys for money, it’s pretty much everything you can do online collected all together. You can choose from a variety of tasks and collect your bounty. Make sure to find legit websites that are not just another scam! Write and publish a Kindle eBook Did you know that you can publish an eBook and make money with the Amazon Kindle store? Today, almost any device supports Kindle app, making your audience huge. Even by setting the tiniest price on your book, you will still earn passively. Start with creating valuable content that anyone will learn from, e.g., Eight Ways to Make Money Online, and then conduct your research. Once you get everything arranged and settled, your book will be bringing you profit for years to come!

Barbaric vs. Barbarous

Barbaric vs. Barbarous Barbaric vs. Barbarous Barbaric vs. Barbarous By Mark Nichol What’s the difference between barbaric and barbarous? The terms are nearly interchangeable, though for two connotations, one term is preferred over the other. Barbaric or barbarous behavior or other characteristics are those that suggest a cultural attainment between savagery and civilization. These adjectives also refer to unrestrained actions or those a civilized person would consider primitive, strange, or uncouth. Barbaric, however, is more appropriate in the sense of cruelty or harshness, while barbarous more strongly implies unsophisticated behavior. Barbarian, the noun form, is also used as an adjective. The origin of these terms is the Latin word barbaria, meaning â€Å"foreign country†; this meaning derives from the Greek term barbaros, meaning â€Å"foreign† or â€Å"strange.† Ultimately, it likely stems from the idea that utterances in unfamiliar languages sound like meaningless babble and can be recorded as something close to â€Å"bar-bar.† (Babble and blabber may be related to barbarian.) Latin usage referred to anyone outside the cultural influence of the Roman Empire, and later connotation of barbarian implied someone who does not speak one’s language; these senses, still later, extended to identify any ill-mannered person. The name Barbara shares this etymology, with the appealing sense of â€Å"exotic† rather than the unattractive one of â€Å"strange†; a saint by that name prompted its popularity among Christians. The root of the proper noun Barbary, which referred to the lands along the north coast of Africa, is of disputed origin. It derives from Berber, an Arabic term for the inhabitants of North Africa outside Egypt, which might have a local origin, might stem from Arabic (with the same sense of â€Å"babbler†), or might be borrowed from Greek. Barber is unrelated to these words and names; it stems from the Latin term barba, meaning â€Å"beard.† That word itself is probably cognate with barber through a common ancestor word. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Misused Words category, check our popular posts, or choose a related post below:Types of RhymeConfusing "Passed" with "Past"Drama vs. Melodrama

Social responsibility of business Essay Example | Topics and Well Written Essays - 500 words

Social responsibility of business - Essay Example Requiring businesses to intervene in social issues is equivalent to asking for more than what businesses owe both government and the society (Sarkar 2005, p.25). Increasing profits is the right thing for businesses to do because engaging in social activities would give them unfairly excessive powers. These powers would cause businesses to control the lives of people through political action, influence on the government and domination using business values. Businesses know how to make profits well but are incompetent pertaining social issues. This incompetence unfolds threefold starting with businesses’ lack of the technical skills requisite to handle social issues. Businesses lack knowledge that is as good as that of the government about what is good for the society and incompetent investments into social issues only wastes stakeholders’ funds (Sarkar 2005, p.26). Overall, the nature and character of free economy requires the function of business to be economic and not social and going against this is tantamount to causing confusion. On the other hand, Friedman could as well have been wrong in light of a number of things. His statement ignored that social activities could have profitable gains in the end. As such, Friedman’s statement focused on the short-term costs and downplayed the long-term benefits that could accrue from businesses engaging social responsibility. Concentrating on making profit only denies businesses a chance to build favorable public image. Businesses need a favorable public image in order to get employees, customers and access to money markets. Businesses should have a conscience even when concentrating on making profit because ethical actions are necessary if a business is to keep its customers and not have them boycotting its good and services (Sarkar 2005, p.27). The possible risks that a socially responsible business dares will make the stock market to raise its stock

Sustainable Supply Chain Management Essay Example | Topics and Well Written Essays - 3750 words

Sustainable Supply Chain Management - Essay Example According to the research findings, it can, therefore, be said that effective and efficient association puts a business in a better position to maximize on its profits; a business needs to put in place effective methods of managing its chains so that it reduces any wastage that may result and at the same time, being friendly to the environment. Currently, the concept of environmental management has become a thorny issue across the globe, this has translated to heavy fines and penalties to those businesses and other entities found violating environmental management practices. For this reason, a business ought to rely on effective use and management of its vehicles so that they do not release most of them to places where effective planning can see the use of only few of them. This is the idea that has led t the establishment of ideas into sustainable chain management. At the same time, it is important to realize the critical need for suppliers in the business and the importance of esta blishing more links. The work of the production and sales department should be to look for better opportunities for cheaper inputs while trying to sustain those suppliers that the business already has. In doing this, the business is able to remain in operation just in case there is a change in the supply environment, prompting the exit of some important suppliers in the business. the need to ensure sustainability and consistency in terms of product delivery into the market has been the ultimate aim of most businesses.

Characterizing HP’s from Leptospira Interrogans

Characterizing HP’s from Leptospira Interrogans Introduction: Genome sequencing projects and genetic engineering has revealed many aspects of complex cellular environment containing large number of proteins. Despite sequences of most of organisms are available and proteins coded are studied experimentally, there are some proteins whose functions are unknown, need to be characterised(5). Such proteins are known as Hypothetical proteins (HP) sequences of which are known but there is no evidence of experimental study(6). There is extensive need to study and classify these hypothetical proteins which can open new way to design drug molecules against infectious organisms. Functional annotation of HP’s involved in infection, drug resistance, and essential biosynthetic pathways is important for development of the potent antibacterials against infectious agents. Improved understanding of these proteins may make them potential targets of antimicrobial drugs [26]. Leptospira interrogans is gram negative spirochete, having an internal flagella is p athogenic which causes Leptospirosis (1)(2), other serovars (strains) are distinguished on the basis of cell surface antigens. These are infectious to animals, but through animal urine can be spread to human(3). Leptospira enters in body via broken skin, mucosa and spreads in body, if immune system fails to stop the growth of bacteria it cause severe hepatic and renal dysfunctions(4). This present study highlights thein silicostudies to characterize HP’s from Leptospira interrogans. Methods: Sequence Retrieval: KEGG (Kyoto Encyclopedia of Gene and Genomes) is a large collection of databases having entries of genes, proteins, pathways in metabolism and diseases, drug and ligands of organism (7). We have selected the Sequences of 12 hypothetical proteins of Leptospira interrogans randomly from KEGG database (www.genome.jpg/kegg).   Pfam: Pfam is curated Protein families database, it uses jackhmmer programme (HMMR3). To give profile HMM ( Hiden Markov Model) with PSI-BLAST, which were searched against UniProt(9). However, to include protein in a family its domain and sequence bit scores must be equal or above the Gathering Thresholds (GA). Pfam gives Pfam A families which are manually curated and Pfam B families generated automatically(8). Batch CD search: Hypothetical Protein sequences were searched for conserved domains at batch CD search, which gives results by using MSA and 3D structures for homologous domains available on Pfam and SMART(9)(10). ExPASy-ProtParam tool: ProtParam tool (www.expasy.org/tools/protparam.html) was used to estimate physicochemical parameters of hypothetical proteins(11). Query protein can be submitted in form of SWISS/TrEMBL ID or protein sequence. Server provides directly calculated values of pI/MW (Isoelectric point, Molecular Weight), Percentage of each amino acid, Extinction coefficient (EC), Instability Index (II)(12), Aliphatic Index (AI) and GRAVY (Grand Average of Hydrophobicity). SOSUI server: Amphiphilicity index and Hydropathy index of query protein sequences were calculated by SOSUI server which categorises protein into cytoplasmic or transmembrane nature(13). Protein-Protein Interaction network: Protein in the cell environment interacts with other proteins, in silico these interactions were studied by STRING v9.1 (Search Tool for Retrieval of Interacting Genes). STRING is a large repository of protein-protein interactions involving functional interactions, stable complexes, and regulatory interactions among proteins(14,15). Figure 1. Shows resulting protein-protein interaction network of selected hypothetical proteins, for better understanding interaction networks should be seen on server site. Disulfide-Bonding in Protein Disulfide bonds among cysteine residues in protein plays an important role in folding it into functional and stable conformation. DISULFIND server utilizes SVM binary server to predict bonding state of cysteins, these cysteins are paired by Recursive Neural Network to show disulfide bridges(16). Protein Structure Prediction: Protein structure prediction server (PS)2 (17) requires query sequence in fasta format to generate 3D structure by comparative modelling(18). Server utilizes consensus strategy to find template using PSI-BLAST and IMPALA. Query sequence and template aligned by T-coffee, PSI-BLAST, and IMPALA [13]. 3D structures are predicted from template using MODELLER and visualised by CHIME, Raster3D. Resulting 3D structural model of selected hypothetical proteins are shown in Figure 2. Ligand Binding site Prediction: Q-site finder(19) server was used for binding site prediction in selected proteins. Server uses energy based methods to find clefts on protein surface for ligands(20). These hot spots for ligand binding have predicted after ranking their physicochemical properties as hydrophobicity, desolvation, electrostatic van der waal potentials. Discussion: ProtParam tool computes different physicochemical parameters depending on the queries submitted to the databases. Isoelectric focusing separates proteins according to pI where pH gradients are developed(21). Predicted pI via server may not be adequate because in case of high number of basic amino acids and lower buffer capacity. By using pH gradients and calculated pI, proteins can be separated experimentally. MW of proteins along with pI is used for the 2D gel electrophoresis. EC shows a light absorbed by a protein relative to their composition at a specific wavelength. EC given (Table 1) are calculated with reference to Tryptophan, Cysteine, Tyrosine (11). Instability index (II) refers to the stability of the protein in test tube(22). Among studied proteins giÇâ‚ ¬24214908, giÇâ‚ ¬24215664, giÇâ‚ ¬24216444, giÇâ‚ ¬24213620, gi|24213945 were found to be unstable, and rest are stable (proteins with II above 40 are unstable). Aliphatic amino acid constitute s the aliphatic index (a relative volume of aliphatic side chains). Increased AI results into a hydrophobic interactions and thus gives thermostatic stability to protein, predicted AI and II shows inverse relation for stability except these two proteins giÇâ‚ ¬24215664 and giÇâ‚ ¬24215909. GRAVY(23) values are a ratio of all hydropathy values of amino acids to the number of residues in sequence. Smaller the GRAVY(23) more hydrophilic is protein, giÇâ‚ ¬24214908 and gi|24213945 proteins found the most hydrophilic. In case of 3D structure hydrophilic domains tends to be on exterior surface, while hydrophobic domains avoids external environment and forms internal core of the protein. Search of family for hypothetical proteins based on conserved domains having consensus sequence in their structure is given in Table 3. Hypothetical protein giÇâ‚ ¬24214908 found to be a member of GH18_CFLE_spore_hydrolase, Cortical fragment Lytic Enzyme bearing a catalytic doma in from glycosyl hydrolase, an enzyme used in breaking a spore peptidoglycans so as to activate it for germination when favourable conditions are available. Hypothetical protein giÇâ‚ ¬24215649 from PDZ_serine_protease involved in protein reassembly and work as a heat shock protein. Protein giÇâ‚ ¬24215664 belongs to Leucine-rich Repeats (LRR), ribonuclease inhibitor like family. LRR are motifs having role in protein interactions in complex networks. S-adenosylmethionine decarboxylase (AdoMetDC) enzyme for biosynthesis of spermine and spermidine by decarboxylation of SAM belongs to Ado_Met_dc family (giÇâ‚ ¬24217373). Pilz domain in giÇâ‚ ¬24213620 is found in bacterial cellulose synthase and other proteins that forms biofilm around a bacterium and involve in effluxing drug(24). Hypothetical protein giÇâ‚ ¬294827583 (FecR superfamily) is involved in Iron transport system in bacterial membranes, Fe3+ (insoluble) loaded on citrate carrier is sensed b y FecR protein found in periplasmic space in bacterial membrane(25). Protein sites are predicted as cytoplasmic, host associated, extracellular, cytoplasmic membrane proteins. SOSOI server predictions (Table 6) shows that positively charged amino acids are more at the end of trans membrane region. Protein-protein interaction study has shown some hypothetical proteins are involved in essential cellular process such as transport across membrane, biosynthesis of molecules, translational regulation. Hypothetical protein giÇâ‚ ¬24214908 (Figure 1) interacts with SUA5 protein which is known as one of translational regulator from YrdC/SUA5 family. Search for giÇâ‚ ¬24215909 shown to be involved in chloride transport with chloride channel protein (EriC gene). Protein giÇâ‚ ¬24217373 found to be interacted with S-layer like protein (slpM) which forms layer around bacteria to attach other surfaces and protect it from environment. Additionally it involve in cell devising p rocesses and transport across membrane. Protein giÇâ‚ ¬294827687 had shown interaction with proteins for bleomycin resistance, chorismate synthase (Trp biosynthesis) and Mammalian Cell entry (MCE) like proteins. Figure 2 shows 3D structures of proteins giÇâ‚ ¬24214908, giÇâ‚ ¬24213620, giÇâ‚ ¬24214753, gi|24213945 predicted from amino acid sequence on PS2 server by using templates 1vf8A, 3bo5A, 1f9zA, and c2efsA respectively. Conclusion: Development of potential bioinformatics tools and databases has opened new platform for in-silico study. Currently it is very needful to annotate and characterize hypothetical proteins in Leptospira interrogans serovar. These hypothetical proteins may have an imperative role in producing many virulence factors and cause serious infection or disease. We have analyzed 12 hypothetical proteins from KEGG database and categorized its physicochemical properties and recognized domains and families using various bioinformatics tools and databases. The structures were modeled and their ligand binding sites were identified. Physicochemical predictions made for hypothetical proteins, which can be used to find therapeutic agents against infections caused by Leptospira interrogans. Some of hypothetical proteins serves as channel proteins, ribosomal proteins or are involved in cell cycle process. Families which were identified for these hypothetical proteins are involved in normal cellular process es and the resistance against drugs. Ligand binding hotspots were found with Q-sitefinder which shown amino acids involved in interaction with ligands. It will help in study of molecular docking for development of potent and effective target against Leptospira infection. Acknowledgement: This study was supported by NIPER Guwahati academic staff. We are very grateful for their excellent support in every manner. References: Chou L-F, Chen Y-T, Lu C-W, Ko Y-C, Tang C-Y, Pan M-J, et al. Sequence of Leptospira santarosai serovar Shermani genome and prediction of virulence-associated genes. Gene [Internet]. 2012;511:364–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23041083 Langston CE, Heuter KJ. Leptospirosis. A re-emerging zoonotic disease. Vet. Clin. North Am. Small Anim. Pract. [Internet]. 2003;33:791–807. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0195561603000263 Kohn B, Steinicke K, Arndt G, Gruber AD, Guerra B, Jansen A, et al. Pulmonary abnormalities in dogs with leptospirosis. J. Vet. Intern. Med. Am. Coll. Vet. Intern. Med. [Internet]. 2010;24:1277–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20738768 Picardeau M, Brenot A, Saint Girons I. First evidence for gene replacement in Leptospira spp. Inactivation of L. biflexa flaB results in non-motile mutants deficient in endoflagella. Mol. Microbiol. [Internet]. 2001;40:189–99. Available from: https://www.scopus.com/inward/record.url?eid=2-s2.0-0035050686partnerID=40md5=ea6dce51e08375c70cdc92eb578e74b1 Adinarayana KPS, Sravani TS, Hareesh C. A database of six eukaryotic hypothetical genes and proteins. Bioinformation. 2011;6:128–30. Hsieh W-J, Pan M-J. Identification Leptospira santarosai serovar shermani specific sequences by suppression subtractive hybridization. FEMS Microbiol. Lett. [Internet]. 2004;235:117–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15158270 Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M. The KEGG resource for deciphering the genome. Nucleic Acids Res. [Internet]. 2004;32:D277–D280. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14681412 http://pfam.sanger.ac.uk/. Punta M, Coggill PC, Eberhardt RY, Mistry J, Tate J, Boursnell C, et al. The Pfam protein families database. Nucleic Acids Res. [Internet]. 2012 Jan [cited 2013 Sep 20];40(Database issue):D290–301. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3245129tool=pmcentrezrendertype=abstract Letunic I, Doerks T, Bork P. SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res. [Internet]. 2011;40:D302–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22053084 Wilkins MR, Gasteiger E, Bairoch a, Sanchez JC, Williams KL, Appel RD, et al. Protein identification and analysis tools in the ExPASy server. Methods Mol. Biol. [Internet]. 1999 Jan;112:531–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10027275 Mohan R, Venugopal S. Computational structural and functional analysis of hypothetical proteins of Staphylococcus aureus. Bioinformation [Internet]. 2012 Jan;8(15):722–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3449381tool=pmcentrezrendertype=abstract Mitaku S, Hirokawa T, Tsuji T. aid in the characterization of amino acid preference at membrane – water interfaces. 2002;18(4):608–16. Lewis ACF, Saeed R, Deane CM. Predicting protein-protein interactions in the context of protein evolution. Mol. Biosyst. [Internet]. 2010;6:55–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20024067 Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. [Internet]. 2013 Jan [cited 2013 Sep 17];41(Database issue):D808–15. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3531103tool=pmcentrezrendertype=abstract Vullo A, Marta VS. Disulfide Connectivity Prediction using Recursive Neural Networks and Evolutionary Information. :1–12. http://ps2.life.nctu.edu.tw. Chen C-C, Hwang J-K, Yang J-M. (PS)2: protein structure prediction server. Nucleic Acids Res. [Internet]. 2006 Jul 1 [cited 2013 Sep 24];34(Web Server issue):W152–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1538880tool=pmcentrezrendertype=abstract http://www.bioinformatics.leeds.ac.uk/qsitefinder. Burgoyne NJ, Jackson RM. Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces. Bioinformatics [Internet]. 2006 Jun 1 [cited 2013 Sep 23];22(11):1335–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16522669 Bjellqvist B, Hughes GJ, Pasquali C, Paquet N, Ravier F, Sanchez JC, et al. The focusing positions of polypeptides in immobilized pH gradients can be predicted from their amino acid sequences. Electrophoresis [Internet]. 1993;14:1023–31. 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Famous graphic designers and illustrators

The most recognized and famous graphic designers and Illustrators are from the US and different countries from Europe, but what about the graphic designers from the Philippines. Kate Morose a famous British artist, and Wham Abaca a Philippine artist who Is not so famous. Two artists that are very good designers and both use pop art and contemporary. Also both work with an explosion of colors. Just looking at their work, you can see the free mind that both have. But Just because Kate Is fromEngland and Wham Is from the Philippines, do not have the same popularity. All around the world you can find people who have an Incredible talent, you do not have to go to England to find good graphic designers. The two illustrators, we just mention, their style is like pop art, with a lot of color and a lot of shapes. Kate Morose use words, with funny letters that make a massage. Wham Abaca, also give us a massage like every artist do, but he just work with images and some time a couple of words. The big difference between this to great artist, are that Skate's work is softer and Wham is most grotesque.Even with this big different, both are good designers that make their ideas flow in their works and looks garish. Skate's and Wham's designs blow up with colors. Kate uses more colors that Wham, she almost use the entire color palette in Just one design and it not looks heavy. But even if Wham is working Just with specific color, all their work is colorful and looks bright. Both make the people turn to see their work, because the bright colors attract their attention. It is difficult to make a good design with a lot of colors, because you have to choose the right tone and make a good contrast when you put them together.Kate and Wham have made a very good Job with that. As you can see in the pictures, both artists try to give massages using their own style and giving life to whatever they want to transmit. Kate gave us very clear what she wants to said, because she uses words, and the words are easy to read. Wham's works Is more like â€Å"one picture tells us more than a thousand words†, because he do not use a lot of words, sometime non. But some of Skate's designs the words are difficult to read and the Wham's pictures are difficult to make a clear message.Even o both reflect their free mind and creatively very well, but not all the people can make a clear message from their creations. As we could saw, designs from a Philippine It Is as well from designs from someone of England. Wham has a unique style, kind pop art, but he put his own touch. He knows how to combine the colors and make them look very attractive, making his wants to give a message, which reflects his thinking. Even if it is look a little bit strange and scary. The world is a place full of persons with great talents that can be found even in places that are not so common like the Philippines.

The Great Gatsby, Invisible Man, And The Adventures Of...

Right Bub Sure it was: The Narrator’s Ability to Control Perceptions From the scrolls in the Library of Alexandria in the third century BC telling the stories of the romans conquering barbarians, to the negative portrayal of political enemies in modern history textbooks, the historian recounting the stories has power over the entire story. Able to describe other seemingly established civilizations in the Americas as savages, European historians were able to control the entire story, portraying themselves as heroes, upon conquering these societies. This narrative power is also present in many examples of modern literature including The Great Gatsby, Invisible Man, and The Adventures of Huckleberry Finn. In these works, the author, like†¦show more content†¦Despite maintaining a powerless position throughout the course of the story, a narrator who imparts his assumptions and perceptions on the descriptions of events ultimately fulfills his need for power by controlling the narrative. Altering the reader’s perception of characters and eve nts, an otherwise powerless narrator is able to fulfill their desire for power. This narrative power is exhibited by the narrators in Junot Diaz’s The Brief Wondrous Life of Oscar Wao. Diaz utilizes different narrators, each with distinct language and perspectives illustrating the possibilities of narrative power. Despite his best efforts to â€Å"share some of his playerly wisdom† (173) and â€Å"fix Oscar’s life†, Yunior is unable to convince Oscar turn his life around and is ultimately powerless with those he cares about(175). Yunior not only failed to convince Oscar to run for more than a few days but also failed on many attempts to persuade Oscar to abort his â€Å"Battle of the Planets routine† (183). This failure to change Oscar’s life is furthered when Oscar â€Å"jumped of the New Brunswick train bridge† (191). Not only had Yunior failed to his â€Å"Oscar Redemption Program† and prevent his attempted suicide but also Yunior was repeatedly rejected by Lola. â€Å"The opposite of the girls [Yunior] usually macked on†, Lola was â€Å"easy to care about† (168). Despite Yunior’s success with many girls

Single Parent Vs Nuclear Family Essay - 847 Words

Single-Parent Families versus Nuclear Families Once in society, it was absurd not to have both parents take care of their children. Parenting, it is a piece of life many people grow up with, and the way it is done keeps changing over time. In today’s society, the two most popular trends in families follow, still, the nuclear family, but now, also the single-parent family dynamic. The single-parent home and nuclear family may seem like they are quite similar, but they do have their differences. Single-parent homes and the nuclear family have differences: financially, affectionately, and just living in general. Financially, single parents have to maintain a steady job in order to support the family. Unlike nuclear families, single parents†¦show more content†¦For example, if one does not have a good job, whether it is low pay or long shifts, and the other parent has the same issue, or is unemployed, they may also feel the same problems as the single parents. The benefit of a nuclear family is that if that something does happen like an emergency, there is another person with them to equal out the work. Single-parent families may display affection differently than the nuclear family. For example, since there is only one parent, the parent may spend more time with the child and have quality time together. There can a time of bonding from just parent to child, but if the parent is busy, the time to display affection may be more difficult to find. Also, some parents do not show affection as often as others, and when only one is in the family, the parent may only express certain types of affection like asking how their children’s day were but can not make it to their sporting events. Unlike single-parent families, nuclear families can display affection easier as a family. Children have two different sources to go to for affection, and each parent may show it in different ways. 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